The 2024 Nobel Prize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for their contributions to the discovery and function of microRNAs. These remarkably short RNA molecules (only 18-24 nucleotides in length) are defined as microRNAs (miRNAs) and are found in all eukaryotic cells, including fungi, plants, and animals. miRNAs play a role in regulating the expression of genes responsible for protein production. Their mode-of-action generally involves suppressing protein-producing genes.
Recent scientific studies have shown that species from taxonomically different kingdoms can regulate each other’s gene expression (cross-kingdom gene regulation)1-5. The most striking finding in this regard is that plant-derived miRNAs can enter human cells and regulate gene expression. In particular, the regulation of genes in mammalian cell pathways by plant-derived miRNAs carried by plant exosomes indicates that these miRNAs have promising potential in biomedical, nanomedical, cosmetic, skincare, and therapeutic applications6-9.
Through our developed ProliCell® technology, we utilize enriched exosomal content and small RNAs obtained from plant stem cells to offer high-tech cosmetic products to the skincare industry. By modulating plant stem cells with elicitors in various compositions and concentrations, we develop products enriched in terms of exosomal and small RNA profiles, including microRNAs. We offer 11 different targeted products to meet the specific needs of the skincare sector.
Through ProliCell® technology, we develop scientific, advanced technology-based, and needs-oriented products in the skincare sector by utilizing the synergistic effect of enriched exosomes and miRNAs derived from plant stem cells. The critical role of miRNAs, which are classified as small RNAs, in skin biology makes them a potential therapeutic target in skincare products, thus forming the basis of ProliCell® technology.