{"id":4872,"date":"2024-11-26T23:15:19","date_gmt":"2024-11-26T20:15:19","guid":{"rendered":"https:\/\/actvbiotech.com\/?p=4872"},"modified":"2024-11-27T00:31:48","modified_gmt":"2024-11-26T21:31:48","slug":"bitki-kokenli-mikrornalar-hakkinda-nobel-buluslari","status":"publish","type":"post","link":"https:\/\/actvbiotech.com\/tr\/bitki-kokenli-mikrornalar-hakkinda-nobel-buluslari\/","title":{"rendered":"Bitki K\u00f6kenli mikroRNA&#8217;lar Hakk\u0131nda Nobel Bulu\u015flar\u0131"},"content":{"rendered":"<div style=\"font-family: Quicksand, serif;\">\n<p style=\"font-family: Quicksand, serif;\">2024 y\u0131l\u0131 Nobel Fizyoloji veya T\u0131p \u00d6d\u00fcl\u00fcne mikroRNA&#8217;lar\u0131n ke\u015ffi ve i\u015flevine y\u00f6nelik katk\u0131lar\u0131ndan dolay\u0131 Victor Ambros ve Gary Ruvkun lay\u0131k g\u00f6r\u00fclm\u00fc\u015flerdir. Olduk\u00e7a k\u0131sa (sadece 18-24 n\u00fckleotid uzunlu\u011funda) olan bu RNA molek\u00fclleri, mikroRNA (miRNA) olarak tan\u0131mlanm\u0131\u015ft\u0131r. miRNA\u2019lar mantar, bitki ve hayvanlar gibi t\u00fcm \u00f6karyotik h\u00fccrelerde yer almaktad\u0131rlar ve miRNA\u2019lar protein \u00fcretiminden sorumlu genlerin ifadesinin d\u00fczenlenmesinde rol oynamaktad\u0131rlar. miRNA\u2019lar\u0131n s\u00f6z konusu etki mekanizmas\u0131 (ing. mode-of-action) genellikle protein \u00fcretim genleri bask\u0131lama y\u00f6n\u00fcndedir<\/p>\n<p>Son zamanlarda ger\u00e7ekle\u015ftirilen bilimsel \u00e7al\u0131\u015fmalar, taksonomik a\u00e7\u0131dan farkl\u0131 alemlere ait t\u00fcrlerin birbirlerinin gen ifadesini d\u00fczenleyebildi\u011fini g\u00f6stermi\u015ftir (cross-kingdom gene regulation)1-5. Bu konuda en dikkat \u00e7ekici bulgu, bitkisel kaynakl\u0131 miRNA&#8217;lar\u0131n insan h\u00fccrelerine girerek gen ifadesini d\u00fczenleyebilmesidir. \u00d6zellikle bitki eksozomlar\u0131 ile ta\u015f\u0131nan bitki kaynakl\u0131 miRNA&#8217;lar\u0131n memeli h\u00fccrelerine ait biyolojik yolaklardaki genleri d\u00fczenlemesi, bu miRNA&#8217;lar\u0131n biyomedikal, nanot\u0131p, kozmetik, cilt bak\u0131m\u0131 alanlar\u0131nda ve terap\u00f6tik uygulamalarda umut verici bir potansiyele sahip oldu\u011funu g\u00f6stermektedir6-9.<\/p>\n<p>Geli\u015ftirdi\u011fimiz ProliCell\u00ae teknolojisi arac\u0131l\u0131\u011f\u0131yla, bitki k\u00f6k h\u00fccrelerinden elde edilen zenginle\u015ftirilmi\u015f eksozomal i\u00e7erik ve k\u00fc\u00e7\u00fck RNA&#8217;lardan (ing. small RNAs) yararlanarak, cilt bak\u0131m\u0131 sekt\u00f6r\u00fcne ileri teknoloji kozmetik \u00fcr\u00fcnler sunmaktay\u0131z. Bitki k\u00f6k h\u00fccrelerini, \u00e7e\u015fitli kompozisyon ve konsantrasyonlardaki elisit\u00f6rler ile mod\u00fcle ederek, eksozomal ve mikroRNA&#8217;lar\u0131 da i\u00e7eren k\u00fc\u00e7\u00fck RNA profili a\u00e7\u0131s\u0131ndan zenginle\u015ftirilmi\u015f \u00fcr\u00fcnler geli\u015ftirmekteyiz. Cilt bak\u0131m sekt\u00f6r\u00fcn\u00fcn spesifik ihtiya\u00e7lar\u0131na y\u00f6nelik olarak, hedeflenmi\u015f 11 farkl\u0131 \u00fcr\u00fcn sunmaktay\u0131z.<\/p>\n<div>\u25cf ProliCell\u00ae-AvocStem Anti-Oksidan<\/div>\n<div>\u25cf ProliCell\u00ae-Centella K\u0131\u015f\u0131kl\u0131k kar\u015f\u0131t\u0131, yara iyi edici<\/div>\n<div>\u25cf ProliCell\u00ae-GoldStem Kaz aya\u011f\u0131 k\u0131r\u0131\u015f\u0131kl\u0131klar\u0131, al\u0131n k\u0131r\u0131\u015f\u0131kl\u0131klar\u0131,<\/div>\n<div>\u25cf ProliCell\u00ae-IsoStem Cilt lekeleri, cilt tonu<\/div>\n<div>\u25cf ProliCell\u00ae-Malva Sa\u00e7 d\u00f6k\u00fclmesine kar\u015f\u0131, sa\u011fl\u0131kl\u0131 sa\u00e7 derisi<\/div>\n<div>\u25cf ProliCell\u00ae-Prunella Kukla \u00e7izgilerine kar\u015f\u0131, nazobial \u00e7izgilere kar\u015f\u0131<\/div>\n<div>\u25cf ProliCell\u00ae-Quince K\u0131\u015f\u0131kl\u0131k giderici, esneklik ve nemlilik sa\u011flay\u0131c\u0131<\/div>\n<div>\u25cf ProliCell\u00ae-Rose \u00c7evre kirlili\u011fine kar\u015f\u0131<\/div>\n<div>\u25cf ProliCell\u00ae-ShineStem G\u00f6z \u00e7evresi, g\u00f6z halkalar\u0131na kar\u015f\u0131<\/div>\n<div>\u25cf ProliCell\u00ae-SymStem K\u0131zar\u0131kl\u0131k giderici<\/div>\n<div>\u25cf ProliCell\u00ae-SlimStem Anti-sel\u00fclit<\/div>\n<p>ProliCell\u00ae teknolojisi arac\u0131l\u0131\u011f\u0131yla, cilt bak\u0131m sekt\u00f6r\u00fcnde bitki k\u00f6k h\u00fccre kaynakl\u0131 zenginle\u015ftirilmi\u015f eksozomlar ve miRNA&#8217;lar\u0131n sinerjistik etkisinden yararlanarak bilimsel, ileri teknolojiye dayal\u0131 ve ihtiyaca y\u00f6nelik \u00fcr\u00fcnler geli\u015ftirmekteyiz. K\u00fc\u00e7\u00fck RNA\u2019lar i\u00e7erisinde s\u0131n\u0131fland\u0131r\u0131lan miRNA&#8217;lar\u0131n cilt biyolojisindeki kritik rol\u00fc, onlar\u0131 cilt bak\u0131m \u00fcr\u00fcnlerinde potansiyel bir terap\u00f6tik hedef haline getirmekte ve b\u00f6ylece ProliCell\u00ae teknolojisinin temelini olu\u015fturmaktad\u0131r.<\/p>\n<div>Do\u00e7. Dr. Vahap ELDEM<\/div>\n<div>\u0130stanbul \u00dcniversitesi Biyoloji B\u00f6l\u00fcm\u00fc<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>2024 y\u0131l\u0131 Nobel Fizyoloji veya T\u0131p \u00d6d\u00fcl\u00fcne mikroRNA&#8217;lar\u0131n ke\u015ffi ve i\u015flevine y\u00f6nelik katk\u0131lar\u0131ndan dolay\u0131 Victor Ambros ve Gary Ruvkun lay\u0131k g\u00f6r\u00fclm\u00fc\u015flerdir. Olduk\u00e7a k\u0131sa (sadece 18-24 n\u00fckleotid uzunlu\u011funda) olan bu RNA molek\u00fclleri, mikroRNA (miRNA) olarak tan\u0131mlanm\u0131\u015ft\u0131r. miRNA\u2019lar mantar, bitki ve hayvanlar gibi t\u00fcm \u00f6karyotik h\u00fccrelerde yer almaktad\u0131rlar ve miRNA\u2019lar protein \u00fcretiminden sorumlu genlerin ifadesinin d\u00fczenlenmesinde rol [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4873,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37,39,40,38,36],"tags":[41,42,43,44,45],"class_list":["post-4872","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","category-gene-regulation","category-micro-rna","category-plant-stem-cell","category-victor-ambros-ve-gary-ruvkun","tag-biotechnology","tag-gene-regulation","tag-micro-rna","tag-plant-stem-cell","tag-victor-ambros-ve-gary-ruvkun"],"_links":{"self":[{"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/posts\/4872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/comments?post=4872"}],"version-history":[{"count":2,"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/posts\/4872\/revisions"}],"predecessor-version":[{"id":4877,"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/posts\/4872\/revisions\/4877"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/media\/4873"}],"wp:attachment":[{"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/media?parent=4872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/categories?post=4872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/actvbiotech.com\/tr\/wp-json\/wp\/v2\/tags?post=4872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}